What is the physiological state produced by repeated drug use that compels ongoing use?

The physiological state produced by repeated drug use that compels ongoing use is physical dependence. When an individual develops physical dependence, their body adapts to the presence of the drug and incorporates it into its normal functioning. This often results in withdrawal symptoms when the substance is not available, creating a strong compulsion to continue using the drug to avoid these unpleasant effects.

Physical dependence encompasses various changes in the body, including alterations in neurotransmitter levels, biological processes, and even hormone regulations, which make it challenging for the person to stop using the drug. Thus, the need to alleviate withdrawal symptoms and maintain normal functioning leads to the ongoing use of the substance.

In contrast, tolerance refers to having to use more of a substance to achieve the same effect over time, while feedback typically relates to processes of information processing or responses, not specifically to drug use. Decoding does not pertain to physiological states in relation to drug use at all. Therefore, among the choices given, physical dependence is the most accurate answer.